JOURNAL INFORMATION

Publication Frequency: Annually (Manuscripts are accepted and published through-out the year)

ISSN: 2600-7207

Life Sciences, Medicine and Biomedicine is an international, open access multidisciplinary journal that welcomes publication in all areas of life sciences, medicine and biomedicine. Some related biological sciences may be considered on a case by case.

Submissions include research letters, reviews and research articles, from basic research, non-clinical, pre-clinical, clinical and related biological sciences. The broad focus of the journal is meant to encourage collaboration between researchers and the diverse research areas. The journal acknowledges research is made up of interlinking branches of science and hopes that the outcome will be beneficial to the scientific community and their stakeholders.

Authors are also encouraged to submit manuscripts that focusses on the investigation of causes of diseases, their epidemiology, diagnostic processes and treatment. Papers that are looking at new methods, recent discoveries and innovation in therapy are also very much welcomed.

Your submissions can include but not limited to some of these areas: drug discovery, natural products and pharmacology, pharmaceutical sciences, microbiology, infectious diseases, halal research, vaccines research, inflammation and related studies, neurosciences, genomics, proteomics, environmental and occupational health, cancer and therapy, stem cell research and therapy, clinical research, nutrition and dietetics, food science, nursing, physiotherapy, public health, bioinformatics, biotechnology, traditional medicines, environmental science, occupational safety, applied sciences, biomedical engineering and biological sciences.

EDITORIAL BOARD

 

SCOPE

Life Sciences, Medicine and Biomedicine is an international, open access multidisciplinary journal that welcomes publication in all areas of life sciences, medicine and biomedicine. Some related biological sciences may be considered on a case by case.

Submissions can include:

  1. Research Article: Original research from basic research, non-clinical, pre-clinical, clinical and related biological sciences. There are no minimum sets of results, experimental protocols or data required. Our top priority is that the research even if it’s a single experiment, is conducted through rigorous and acceptable scientific testing and methodologies, are novel and original.
  2. Review: Reviews consist of a comprehensive analysis of existing literature on a specific topic, including presentation of current findings from published literatures. Reviews can be in a form of literature reviews, meta-analysis or systematic reviews.
  3. Opinion: This article type is the expert opinion of an author or authors on an area of interest. Authors can present their perspective or interpretation or reviews on an article or data presented within and at the same time discuss in a broader term how the area of research can be further improved, explored and investigated.
  4. Clinical Case: This section will include papers demonstrating data and specifics of patient(s) in a hospital/clinical setting.


Authors are also encouraged to submit manuscripts that focusses on the investigation of causes of diseases, their epidemiology, diagnostic processes and treatment. Papers that are looking at new methods, recent discoveries and innovation in therapy are also very much welcomed.

Your submissions can include but not limited to some of these areas:

  1. Drug discovery
  2. Natural products and pharmacology
  3. Pharmaceutical sciences
  4. Microbiology
  5. Infectious diseases
  6. Halal research
  7. Vaccines research
  8. Inflammation research
  9. Neurosciences
  10. Genomics
  11. Proteomics
  12. Environmental and occupational health
  13. Cancer and therapy
  14. Stem cell research and therapy
  15. Clinical research
  16. Nutrition and dietetics
  17. Food science
  18. Nursing
  19. Physiotherapy
  20. Public health
  21. Bioinformatics
  22. Biotechnology
  23. Traditional medicines
  24. Environmental science
  25. Occupational safety
  26. Applied sciences
  27. Biomedical engineering
  28. Biological sciences

ABSTRACTING & INDEXING

Life Sciences, Medicine and Biomedicine is currently indexed by Google Scholar and MyJurnal. MyJurnal is the Malaysian Citation Centre (Ministry of Education, Malaysia).

ARTICLE PROCESSING CHARGE

Life Sciences, Medicine and Biomedicine is an Open Access journal. To allow global audience access to the manuscripts we publish, and to ensure every segment of the population has free and unimited access to these resources, we work hard to keep the cost of the entire publication process as minimum as possible.

In fact, at the moment, the cost is being absorbed by voluntary efforts of individuals as well as the publisher. We are committed to continue this tradition.

We will be introducing the Article Processing Charge at some point, especially when more resources are needed processing accepted manuscripts. We will not be charging for submission or reviews, but only for those accepted manuscripts. We want to ensure when there are fees, it will be kept at a minimal amount.

However, until further notice, the article processing charge (APC) for all accepted manuscripts are WAIVED and FREE.

LATEST ARTICLES

Effects of EPA+DHA from yellow-stripe scad and salmon on platelet and endothelial cell-related cytokines of healthy overweight Malaysians


Introduction: Overweight currently has become a major global burden. Salmon is one of the major sources for fish oil to treat inflammatory related cardiovascular diseases. Yellow-stripe scad (YSS) on the other hand, is a local Malaysian fish which can be a good substitute for salmon; however, the therapeutic effects of YSS is still unclear. Objective: Therefore, this study compared the nutritional values EPA+DHA of YSS and salmon on body mass index (BMI), leptin and activation markers for both platelet and endothelial cell. Methods: Healthy overweight Malaysian adults (n=45), aged 21-55  years old, were recruited for 6-months cross-over trial study. They were randomised equally to receive eight weeks of either steamed whole YSS fish or salmon fillet, for three days per week, obtaining approximately 7000 mg EPA+DHA weekly. The diets were switched after an eight-week washout period. Baseline dietary fish intakes were similar in the two groups. Both YSS and Salmon elevated EPA+DHA level of  leptin, platelet  and endothelial cell phospholipid membrane (data not shown). Body mass index (BMI), serum leptin and biomarkers of platelet and endothelial cell activation (sCD40L, P-selectin, IL-1β, vWF and VCAM-1) were evaluated.  Results: The comparison of data indicated no significant difference was observed after the treatment with YSS and salmon on pre and post BMI (p>0.05). However, there were significant differences observed in serum leptin for YSS-baseline group I and salmon-baseline group II (p<0.05).  Significant changes were observed in serum P-selectin, sCD40L and IL-1β in YSS-baseline group I (p<0.05) but not in VCAM-1 (p>0.05). Significant decreased were also observed in serum vWF and VCAM-I in salmon/baseline group II (p<0.05), but not in P-selectin, sCD40L and IL-1β (p>0.05).


Proceedings of the 5th International Anatomical Sciences & Cell Biology Conference


The IASCBC 2018 provideded a platform that brings together scientists, researchers, academicians, post-graduates and experts from the fields of anatomy, microscopy and cell biology, as well as a broad range of medical, biomedical and health sciences discipline to share the current developments in their respective areas. For the first time, Malaysia hosted the much anticipated conference at the prestigious Berjaya University College at Kuala Lumpur.


Inhibited Dopamine Synthesizing Cell Model of AADC Deficiency


Introduction: Aromatic L-amino acid decarboxylase deficiency (AADC) is a rare autosomal recessive pediatric neurotransmitter disease. To date it remains poorly understood mainly due to an absence of a disease model. The dopaminergic neuroblastoma cell SH-SY5Y was chosen to develop our AADC deficiency model. These cells are not native dopamine synthesizers. Objective: To develop a dopamine-producing cellular model of AADC deficiency using SH-SY5Y neuroblastoma cells. Methods: Dopamine pathway proteins were identified with Western Blotting. Dopaminergic differentiation was attempted using all-trans retinoic acid (ATRA) with dopamine detection via HPLC-ECD post alumina extraction. Treatment with L-DOPA provided SH-SY5Y with excess precursor. RT-PCR was used to determine the expression of markers of mature neurons. Results: Western Blot screening identified AADC, dopamine β-hydroxylase and tyrosine hyrdoxylase proteins, indicative of a dopaminergic pathway. ATRA was unsuccessful in producing dopamine from the cells. L-DOPA treatment however, generated dopamine first visible as a HPLC-ECD peak 30 minutes post-incubation. Prior to this, SH-SY5Y dopamine synthesis from L-DOPA has never been documented. This de novo synthesis is then inhibited using benserazide to form our AADC deficiency cell model. RT-PCR showed that SH-SY5Y cells express markers of mature neurons in its ‘native’ state and is not affected by L-DOPA and benserazide treatment. This cell model will potentially benefit many areas of AADC deficiency research. Conclusion: SH-SY5Y cells   produced HPLC-ECD measureable amounts of dopamine with the addition of L-DOPA.    Our model of AADC deficiency is generated by quelling the dopamine production with Benserazide.


Torque Teno Virus and Hepatitis: A review on correlation.


Torque teno virus (TTV) is one of the “orphan” virus that have been discovered almost two decades ago, with little information on the relationship of the infection to any diseases. It is one of the 45% of commensal virus which was found throughout the population and becoming one of the most extensively studied viruses on its prevalence among various level of health status. From healthy blood donors to patients who suffered severe illness, TTV infection level seems to be high and the findings has triggered an interest from the researcher. Even though the study on TTV prevalence is actively performed, the actual pathogenesis of TTV to any specific diseases is yet to be ascertained. Many suggestions on the possible association of TTV infection with severe diseases such as acute respiratory diseases, liver-related diseases and even cancer have been discussed. However, one type of diseases which might have an association with TTV is hepatitis. Albeit, it remains a theory as the actual pathogenicity of TTV is not fully understood.


Absence of 1061C deletion in A2 blood subgroup validated through gene sequencing in the Malaysian population


ABO blood grouping is an important antigenic blood typing tools in blood transfusion and organ transplants. Mismatching of blood during transfusion would lead to undesired transfusion reactions. Due to rare occurrence of rare blood group such as A2 subtype, regular blood grouping technique would have missed the identification of blood group. In this study, the identification of A2 subgroup using routine serological technique was validated via DNA sequencing technique. A total of 656 students participated in this study consist of Malay (87.0 %), Chinese (0.4 %), Indian (11.4 %) and others ethnic group (0.9%) respectively. Monoclonal antisera A, B, AB, D, A1 lectin and H lectin were used to identify the antigen on red blood cells. DNA sequence analysis was applied to examine single nucleotide polymorphisms (SNPs) at position 467 (substitution of C>T) and 1061 (deletion of C) on coding region of ABO gene. Our findings showed of 656 blood samples, 256 (39.0%) were blood group O, 190 (29.0%) were blood group B, 179 (27.3%) were blood group A and 31(4.7%) were blood group AB. The frequency of A1 subgroup is 177 (99.0%) and A2 subgroup is 2 (1.0%). From 179 A blood group, only 2 samples showed negative reaction towards anti-A1 lectin. DNA sequence analysis revealed the SNPs at nucleotide 1061 position in sample 2, however sample 1 did not have this mutation and the subgroup was not identified. DNA sequencing provides a precise and high accuracy in identification of A subgroups.


Medicinal bioactive compounds to functional foods from geochemical signatures marine biomasses: sea cucumbers, macroalgae and crown of thorns biomasses


Recognition of health benefits associated with consumption of marine derived biomasses is one of the most promising developments in human nutrition and disease-prevention research. This endeavor for bioactives and functional ingredients discovery from marine sources is “experience driven,” as such the search for therapeutically useful synthetic drugs, and functional components is like “looking for a needle in a haystack,” thus a daunting task. Zoonotic infection, adulteration, global warming and religious belief can be the star-gate barrier: - For example, the outsourcing for Glycosaminoglycans (GAGs), a pharmacologically bioactive compound have emerged as novel biomarkers and molecular players both within tumor cells and their microenvironment, as they integrate signals from growth factors, chemokines, integrins, and cell-cell matrix adhesion. As such, worldwide initiatives in outsourcing from geochemical signatures marine biomasses are flourishing. Most of these scientific interests are related to marketable compounds optimised via biotechnology applications. Approximately 50% of the US FDA approved drugs during 1981–2002 consist of either marine metabolites or their synthetic analogs. These bioactive compounds acts as antioxidant, peptides, chitoligosaccharides derivatives, sulfated polysaccharides, phlorotannins and carotenoids. Highlights from works to harness and provide scientific support to folk medicine much claimed legacy, pertaining to geochemical signatures vouchered sea cucumbers, macroalgae and crown of thorns starfish will be extrapolated.


Effects of Melicope ptelifolia Aqueous Extract on Sperm Parameters and Testosterone Level in Sprague-Dawley Rats


The increasing number of prevalence infertility cases is becoming a major public health problem in developing countries due to changes in diet and lifestyle. Melicope ptelefolia is known for its health benefit as a sex enhancing effect among the Malays folk however there is no clinical data to prove it until these days. The main aim of the present study is to identify the effects of Melicope ptelifolia Aqueous extract (MPAE) on Sperm Parameters and Testosterone Level . A total of 30 male Sprague Dawley rats were divided equally into five different groups. MPAE was given by orally gavage for 28 days at a dose of 100mg/kg, 200 mg/kg and 500 mg/kg body weight to the animals of group II (n=6), III (n=6) and IV (n=6), respectively. The animals of group I (control, n=6) had distilled water and group V had sildenafil citrate. Results were analyzed using one way ANOVA test and the data were significant at p<0.05. Oral administration of MPAE extract showed an increased sperm count and sperm viability. Oral administration of the MPAE resulted a significant increased (p<0.05) for Group II, III and IV in sperm count and sperm morphology. A significant increased increased was recorded for Group I, II, III and IV in sperm viability. However, sperm vitality remained normal in all the groups. From our present experimental findings we are tempted to suggest that the MPAE could be a potential male fertility agent.


Profiles and Biological Values of Sea Cucumbers: A Mini Review


Sea cucumbers, blind cylindrical marine invertebrates that live in the ocean intertidal beds have more than thousand species available of varying morphology and colours throughout the world. Sea cucumbers have long been exploited in traditional treatment as a source of natural medicinal compounds. Various nutritional and therapeutic values have been linked to this invertebrate. These creatures have been eaten since ancient times and purported as the most commonly consumed echinoderms. Some important biological activities of sea cucumbers including anti-hypertension, anti-inflammatory, anti-cancer, anti-asthmatic, anti-bacterial and wound healing. Thus, this short review comes with the principal aim to cover the profile, taxonomy, together with nutritional and medicinal properties of sea cucumbers.


Invadopodia Formation is a Critical Step in Cancer Cell Invasion: The Effect of Passage Number on Invadopodia Formation in MDA-MB-231 Breast Cancer Cell Line


High invasive cancer cells are thought to recruit specialised actin-rich protrusions for invasion in metastasis process. These protrusions are termed invadopodia. To study invadopodia formation, one of the first challenges faced by researchers has been to optimise the cell line passage number in order to be used for the invadopodia assay. Therefore, this study aims to investigate the effects of the passage number on invadopodia formation in MDA-MB-231 breast cancer cell line. Invadopodia assay was used to achieve the aim of the study. The results provided evidence that invadopodia formation is affected by the high passage number. The cells were also tested with dimethyloxalylglycine (DMOG) a hypoxic mimicking agent which is known to be an invadopodia inducer, the results showed that the cells in low passage number (P7) treated with DMOG increase the cells forming invadopodia, while the cells with high passage number (P35) showed that DMOG fails to stimulate the cells to form invadopodia. Furthermore, the cells with high passage number after passage 15 are starting to lose the ability to degrade the gelatin. In conclusion, this study suggests that only cells with a low passage number, less than passage 15 should be used in the study of invadopodia formation to obtain the results in the search for molecular targets and signaling at invadopodia.


Effect of Open Top Chamber as Global Warming Model on Soil Chemical Properties and Microbial Growth


Global warming is the main concern in today’s century as it comes with numerous side effects on the natural environment. Open Top Chambers (OTC) consist of metal constructions with transparent vertical side-walls and a frustum on top. An opening in the middle of the frustum allows an air exchange to reduce temperature and humidity effects in the chamber. The size of the open top chamber which is located in Universiti Putra Malaysia is slanted 60o, 50cm tall, 2.08m basal diameter hexagon chamber. The Open Top chamber experiments were carried out to determine how much global warming has affected and is still affecting the temperature, pH, the moisture and the growth of the microbes in the tropical soil. The aim of this study is to elucidate the effects of temperature increase on the soil microbes’ population and on the pH of the soil. The study was conducted to observe the effect of heat on soil microbes, and the pH of the soil which was collected on the same day for 6 consecutive months. The microbes values were then used for Colony Forming Unit (CFU) value calculations. The effects of OTCs on mean temperature showed a large range of CFU values throughout the 6 months but did not differ significantly between studies. Increases in mean monthly and diurnal temperature were strongly related, indicating that the presence of warming effect by the OTCs. Such predictive power allows a better mechanistic understanding of observed biotic response to experimental warming. This study will be useful for the understanding of the global warming effect on microbes. The open top chamber has proven to be one of the effective model for global warming research and data collected especially on the growth of soil microbial obtained would be off great use for further experiments.


GUIDE FOR AUTHORS

As part of the submission process, authors are required to check off their submission's compliance with all of the following items, and submissions may be returned to authors that do not adhere to these guidelines.

  • The submission has not been previously published, nor it is under review / considered for publication in any other journal (or an explanation has been provided in Comments to the Editor).
  • The submission file is in OpenOffice or Microsoft Word.
  • Where available, URLs for the references have been provided.
  • The text is 1.5 spaced; uses a 10-point Calibri font; employs italics, rather than underlining (except with URL addresses); and all illustrations, figures, and tables are placed within the text at the appropriate points, rather than at the end.
  • The text adheres to the stylistic and bibliographic requirements outlined in the Author Guidelines.
  • The author(s) confirm that they have full permission for the use of images, formulas, chemical structures and any other copyright materials from their rightful owners. The author(s) also agree to accept full responsiility for the use of these copyright materials and will not hold the Journal and it's Publisher responsible for any claims arising from the use of these materials.
  • The authors and all contributors including financiers agree to the Terms & Conditions of the Publisher. The open access article will be distributed based on the terms and conditions of the Creative Commons Attribution (CC BY) license https://creativecommons.org/licenses/by-sa/4.0/

 

Author Guidelines

You are required to follow the guidelines below for manuscript submission to the Life Sciences, Medicine and Biomedicine.

  • Your manuscript must be submitted in a single Microsoft Word document, together with all figures, diagrams and images.
  • In general, the body of your manuscript must contain introduction, materials and methods, results, discussion, conclusion, acknowledgement, disclosures and references. Sections and sub-sections must be numbered systematically (1.0 Introduction, 2.0 Materials & Methods, 2.1 Chemicals, 2.2 Synthesis etc.)
  • It should state the chemicals or drugs used, experimental models and other relevant information.
  • If your study requires ethical clearance, you must provide the necessary approval codes by your institution.
  • Figures / diagrams / images must be embedded in the manuscript and must appear immediately after it is mentioned in the text. Images must be in image format (JPEG/GIF/BMP).
  • You can also additionally attach a PDF file of all your figures in one file. Ensure all figures are saved in high resolution for clarity.
  • All figures must be supported by a caption. Captions must be provided separately and not saved together with the images. The captions must be provided in text after the references in the manuscript file.
  • You are encouraged to include a graphical abstract, however, it is not compulsory. The graphical abstract should be attached as a separate file in image format (JPEG/GIF/BMP).
  • Your manuscript should contain the following in sequence:
    1. Title that is concise.
    2. Names of author and co-authors and their respective affiliations. All the author’s names must be mentioned in full and spelled correctly. All affiliation must be provided with a lowercase superscript after the author’s names and in the front of their respective address. The affiliation must include a full address including the postcode and country.
    3. The Corresponding author must be indicated with the (*) sign at the end of the corresponding author’s name. All communications will be only between the journal and the corresponding author. It is also the responsibility of the corresponding author to obtain full permission and consent from all the co- authors regarding the submitted work. All authors are fully responsible to accuracy and reliability of the submitted work.
    4. Abstract should not be more than 300 words. References should not be included in the abstract and it must be divided into Introduction, Objectives, Materials and Methods, Results and Conclusions.
    5. A maximum of 5 keywords.
    6. A short title.
    7. Page numbers.
    8. All abbreviations must be spelled out the first time it’s mentioned in the manuscript.
    9. Tables and Figures must be accurately numbered while referred in the text. Authors must agree that they have or have obtained permission to use the images provided in the manuscript. This must be mentioned in the cover letter.
    10. You must state any conflict of interest in the disclosure section. If there is none, you must state the following: The authors declare no conflicts of interest in this work.
    11. Ensure that the references used throughout the manuscript is the APA (American Psychological Association) Style.
    12. Acknowledgements should be included before references. You can mention your funding agencies or sources and include the respective grant numbers in this section.

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