Microplastics - an emerging silent menace to public health
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Microplastics, plastic additives, translocation, health

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Pang, L.-Y., Sonagara, S., Oduwole, O., Gibbins, C., & Kang Nee, T. (2021). Microplastics - an emerging silent menace to public health. Life Sciences, Medicine and Biomedicine, 5(10). https://doi.org/10.28916/lsmb.5.10.2021.72


Over the past few decades, microplastics have become increasingly ubiquitous in the environment and now contaminate the bodies of many living organisms, including humans. Microplastics, as defined here, are plastics within the size range 0.1 μm and 5 mm and are a worrying form of pollution due to public health concerns. This mini-review aims to summarise the route of entry of microplastics into humans and explore the potential detrimental health effects of microplastics. Trophic transfer is an important pathway for microplastic to be transferred across different groups of organisms, with ingestion is regarded as one of the major routes of exposure for humans. Other pathways include inhalation and dermal contact. The health consequences of microplastics manifest because these materials can translocate into the circulatory system and accumulate in the lungs, liver, kidney, and even brain, regardless of the route of entry. Health effects include gastrointestinal disturbances such as inflammation and gut microbiota disruption, respiratory conditions, neurotoxicity and potential cancers. Overall, while it is apparent that microplastics are causing adverse effects on different biological groups and ecosystems, current research is largely focused on marine organisms and aquaculture. Therefore, more studies are needed to investigate specific effects in mammalian cells and tissues, with more long-term epidemiological studies needed on human population considered to be at high-risk due to socioeconomic or other circumstance. Knowledge of the toxicity and long-term health impacts of microplastics is currently limited and requires urgent attention.

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Abbasi, S., Keshavarzi, B., Moore, F., Turner, A., Kelly, F. J., Dominguez, A. O., & Jaafarzadeh, N. (2019). Distribution and potential health impacts of microplastics and microrubbers in air and street dusts from Asaluyeh County, Iran. Environmental Pollution, 244, 153-164.


Atis, S., Tutluoglu, B., Levent, E., Ozturk, C., Tunaci, A., Sahin, K., … Nemery, B. (2005). The respiratory effects of occupational polypropylene flock exposure. European Respiratory Journal, 25(1), 110-117.


Barboza, L. G. A., Dick Vethaak, A., Lavorante, B. R. B. O., Lundebye, A. K., & Guilhermino, L. (2018). Marine microplastic debris: An emerging issue for food security, food safety and human health. Marine Pollution Bulletin, 133(January), 336-348.


Barboza, L. G. A., Vieira, L. R., Branco, V., Figueiredo, N., Carvalho, F., Carvalho, C., & Guilhermino, L. (2018). Microplastics cause neurotoxicity, oxidative damage and energy-related changes and interact with the bioaccumulation of mercury in the European seabass, Dicentrarchus labrax (Linnaeus, 1758). Aquatic Toxicology, 195, 49-57.


Brennecke, D., Ferreira, E. C., Costa, T. M. M., Appel, D., da Gama, B. A. P., & Lenz, M. (2015). Ingested microplastics (>100μm) are translocated to organs of the tropical fiddler crab Uca rapax. Marine Pollution Bulletin, 96(1-2), 491-495.


Browne, M. A., Crump, P., Niven, S. J., Teuten, E., Tonkin, A., Galloway, T., & Thompson, R. (2011). Accumulation of microplastic on shorelines woldwide: Sources and sinks. Environmental Science and Technology, 45(21), 9175-9179.


Browne, M. A., Dissanayake, A., Galloway, T. S., Lowe, D. M., & Thompson, R. C. (2008). Ingested microscopic plastic translocates to the circulatory system of the mussel, Mytilus edulis (L.). Environmental Science and Technology, 42(13), 5026-5031.


Burkhart, J., Piacitelli, C., Schwegler-Berry, D., & Jones, W. (1999). Environmental study of nylon flocking process. Journal of Toxicology and Environmental Health - Part A, 57(1), 1-23.


Carding, S., Verbeke, K., Vipond, D. T., Corfe, B. M., & Owen, L. J. (2015). Dysbiosis of the gut microbiota in disease. Microbial Ecology in Health & Disease, 26(0).


Catarino, A. I., Macchia, V., Sanderson, W. G., Thompson, R. C., & Henry, T. B. (2018). Low levels of microplastics (MP) in wild mussels indicate that MP ingestion by humans is minimal compared to exposure via household fibres fallout during a meal. Environmental Pollution, 237, 675-684.


Cho, Y., Shim, W. J., Jang, M., Han, G. M., & Hong, S. H. (2019). Abundance and characteristics of microplastics in market bivalves from South Korea. Environmental Pollution, 245, 1107-1116.


Cortez Pimentel, J., Avila, R., & Galvao Lourenco, A. (1975). Respiratory disease caused by synthetic fibres: a new occupational disease. Thorax, 30(2), 204-219.


Cox, K. D., Covernton, G. A., Davies, H. L., Dower, J. F., Juanes, F., & Dudas, S. E. (2019). Human Consumption of Microplastics. Environmental Science and Technology, 53(12), 7068-7074.


De Sales-Ribeiro, C., Brito-Casillas, Y., Fernandez, A., & Caballero, M. J. (2020). An end to the controversy over the microscopic detection and effects of pristine microplastics in fish organs. Scientific Reports, 10(1).


Della Torre, C., Bergami, E., Salvati, A., Faleri, C., Cirino, P., Dawson, K. A., & Corsi, I. (2014). Accumulation and embryotoxicity of polystyrene nanoparticles at early stage of development of sea urchin embryos Paracentrotus lividus. Environmental Science and Technology, 48(20), 12302-12311.


Deng, Y., Zhang, Y., Lemos, B., & Ren, H. (2017). Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure. Scientific Reports, 7(April), 1-10.


Ding, J., Zhang, S., Razanajatovo, R. M., Zou, H., & Zhu, W. (2018). Accumulation, tissue distribution, and biochemical effects of polystyrene microplastics in the freshwater fish red tilapia (Oreochromis niloticus). Environmental Pollution, 238, 1-9.


Dong, C. Di, Chen, C. W., Chen, Y. C., Chen, H. H., Lee, J. S., & Lin, C. H. (2020). Polystyrene microplastic particles: In vitro pulmonary toxicity assessment. Journal of Hazardous Materials, 385, 121575.


Dris, R., Gasperi, J., Saad, M., Mirande, C., & Tassin, B. (2016). Synthetic fibers in atmospheric fallout: A source of microplastics in the environment? Marine Pollution Bulletin, 104(1-2), 290-293.


Duis, K., & Coors, A. (2016). Microplastics in the aquatic and terrestrial environment: sources (with a specific focus on personal care products), fate and effects. Environmental Sciences Europe, 28(1), 1-25.


Egbeocha, C. O., Malek, S., Emenike, C. U., & Milow, P. (2018, September 19). Feasting on microplastics: Ingestion by and effects on marine organisms. Aquatic Biology, Vol. 27, pp. 93-106.


Ellen MacArthur Foundation. (2016). The New Plastics Economy: Rethinking the future of plastics. Ellen MacArthur Foundation, (January), 120. Retrieved from https://www.ellenmacarthurfoundation.org/publications/the-new-plastics-economy-rethinking-the-future-of-plastics

Enyoh, C. E., Verla, A. W., Verla, E. N., Ibe, F. C., & Amaobi, C. E. (2019). Airborne microplastics: a review study on method for analysis, occurrence, movement and risks. Environmental Monitoring and Assessment, 191(11).


Essel, R., Ahrens, R. H., Engel, L., & Carus, M. (2015). Sources of microplastics relevant to marine protection. In Umweltbundesamt. Retrieved from https://www.umweltbundesamt.de/sites/default/files/medien/378/publikationen/texte_64_2015_sources_of_microplastics_relevant_to_marine_protection_1.pdf

European-Plastics. (2015). An analysis of European plastics production, demand and waste data. In Plastics - the Facts.

Fackelmann, G., & Sommer, S. (2019). Microplastics and the gut microbiome: How chronically exposed species may suffer from gut dysbiosis. Marine Pollution Bulletin, Vol. 143, pp. 193-203.


Farrell, P., & Nelson, K. (2013). Trophic level transfer of microplastic: Mytilus edulis (L.) to Carcinus maenas (L.). Environmental Pollution, 177, 1-3.


Frias, J. P. G. L., & Nash, R. (2019). Microplastics: Finding a consensus on the definition. Marine Pollution Bulletin, 138, 145-147.


Galloway, T. S. (2015). Micro- and nano-plastics and human health. In Marine Anthropogenic Litter (pp. 343-366).


Gong, M., Zhang, Y., & Weschler, C. J. (2014). Measurement of phthalates in skin wipes: Estimating exposure from dermal absorption. Environmental Science and Technology, 48(13), 7428-7435.


Hahladakis, J. N., Velis, C. A., Weber, R., Iacovidou, E., & Purnell, P. (2018). An overview of chemical additives present in plastics: Migration, release, fate and environmental impact during their use, disposal and recycling. Journal of Hazardous Materials, Vol. 344, pp. 179-199.


Jambeck, J. R., Geyer, R., Wilcox, C., Siegler, T. R., Perryman, M., Andrady, A., … Law, K. L. (2015). Plastic waste inputs from land into the ocean. Science, 347(6223), 768-771.


Jin, Y., Lu, L., Tu, W., Luo, T., & Fu, Z. (2019). Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice. Science of the Total Environment, 649, 308-317.


Jin, Y., Xia, J., Pan, Z., Yang, J., Wang, W., & Fu, Z. (2018). Polystyrene microplastics induce microbiota dysbiosis and inflammation in the gut of adult zebrafish. Environmental Pollution, 235, 322-329.


Karami, A., Golieskardi, A., Ho, Y. Bin, Larat, V., & Salamatinia, B. (2017). Microplastics in eviscerated flesh and excised organs of dried fish. Scientific Reports, 7(1), 1-9.


Koelmans, A. A., Bakir, A., Burton, G. A., & Janssen, C. R. (2016). Microplastic as a Vector for Chemicals in the Aquatic Environment: Critical Review and Model-Supported Reinterpretation of Empirical Studies. Environmental Science and Technology, Vol. 50, pp. 3315-3326.


Lauby-Secretan, B., Loomis, D., Grosse, Y., El Ghissassi, F., Bouvard, V., Benbrahim-Tallaa, L., … Straif, K. (2013). Carcinogenicity of polychlorinated biphenyls and polybrominated biphenyls. The Lancet Oncology, 14(4), 287-288.


Lehner, R., Weder, C., Petri-Fink, A., & Rothen-Rutishauser, B. (2019). Emergence of Nanoplastic in the Environment and Possible Impact on Human Health. Environmental Science and Technology, 53(4), 1748-1765.


Lehtiniemi, M., Hartikainen, S., Näkki, P., Engström-Öst, J., Koistinen, A., & Setälä, O. (2018). Size matters more than shape: Ingestion of primary and secondary microplastics by small predators. Food Webs, 17.


Lei, L., Liu, M., Song, Y., Lu, S., Hu, J., Cao, C., … He, D. (2018). Polystyrene (nano)microplastics cause size-dependent neurotoxicity, oxidative damage and other adverse effects in Caenorhabditis elegans. Environmental Science: Nano, 5(8), 2009-2020.


Li, B., Ding, Y., Cheng, X., Sheng, D., Xu, Z., Rong, Q., … Zhang, Y. (2020). Polyethylene microplastics affect the distribution of gut microbiota and inflammation development in mice. Chemosphere, 244(5), 690-697.


Mastrangelo, G., Fedeli, U., Fadda, E., Milan, G., Turato, A., & Pavanello, S. (2003). Lung cancer risk in workers exposed to poly(vinyl chloride) dust: A nested case-referent study. Occupational and Environmental Medicine, 60(6), 423-428.


Mastrangelo, Giuseppe, Fedeli, U., Fadda, E., Valentini, F., Agnesi, R., Magarotto, G., … Martines, D. (2004). Increased risk of hepatocellular carcinoma and liver cirrhosis in vinyl chloride workers: Synergistic effect of occupational exposure with alcohol intake. Environmental Health Perspectives, 112(11), 1188-1192.


McGoran, A. R., Clark, P. F., Smith, B. D., & Morritt, D. (2020). High prevalence of plastic ingestion by Eriocheir sinensis and Carcinus maenas (Crustacea: Decapoda: Brachyura) in the Thames Estuary. Environmental Pollution, 265.


Nguyen, T. L. A., Vieira-Silva, S., Liston, A., & Raes, J. (2015). How informative is the mouse for human gut microbiota research? DMM Disease Models and Mechanisms, 8(1), 1-16.


Pedà, C., Caccamo, L., Fossi, M. C., Gai, F., Andaloro, F., Genovese, L., … Maricchiolo, G. (2016). Intestinal alterations in European sea bass Dicentrarchus labrax (Linnaeus, 1758) exposed to microplastics: Preliminary results. Environmental Pollution, 212, 251-256.


Prata, J. C., da Costa, J. P., Lopes, I., Duarte, A. C., & Rocha-Santos, T. (2020). Environmental exposure to microplastics: An overview on possible human health effects. Science of the Total Environment, 702.


Praveena, S. M., Shaifuddin, S. N. M., & Akizuki, S. (2018). Exploration of microplastics from personal care and cosmetic products and its estimated emissions to marine environment: An evidence from Malaysia. Marine Pollution Bulletin, 136, 135-140.


Qiao, R., Sheng, C., Lu, Y., Zhang, Y., Ren, H., & Lemos, B. (2019). Microplastics induce intestinal inflammation, oxidative stress, and disorders of metabolome and microbiome in zebrafish. Science of the Total Environment, 662, 246-253.


Ribeiro, F., Garcia, A. R., Pereira, B. P., Fonseca, M., Mestre, N. C., Fonseca, T. G., … Bebianno, M. J. (2017). Microplastics effects in Scrobicularia plana. Marine Pollution Bulletin, 122(1-2), 379-391.


Ritchie, H. (2019). Seafood Production. Retrieved November 9, 2020, from OurWorldInData.org website: https://ourworldindata.org/seafood-production

Rochman, C. M., Hoh, E., Kurobe, T., & Teh, S. J. (2013). Ingested plastic transfers hazardous chemicals to fish and induces hepatic stress. Scientific Reports, 3.


Rochman, C. M., Kross, S. M., Armstrong, J. B., Bogan, M. T., Darling, E. S., Green, S. J., … Veríssimo, D. (2015). Scientific Evidence Supports a Ban on Microbeads. Environmental Science and Technology, 49(18), 10759-10761.


Schwabl, P., Koppel, S., Konigshofer, P., Bucsics, T., Trauner, M., Reiberger, T., & Liebmann, B. (2019). Detection of various microplastics in human stool: A prospective case series. Annals of Internal Medicine, 171(7), 453-457.


Shao, L., Wang, C., He, J., Wu, X., & Cheng, Y. (2013). Hepatopancreas and gonad quality of chinese mitten crabs fattened with natural and formulated diets. Journal of Food Quality, 36(3), 217-227.


Sharma, M. D., Elanjickal, A. I., Mankar, J. S., & Krupadam, R. J. (2020). Assessment of cancer risk of microplastics enriched with polycyclic aromatic hydrocarbons. Journal of Hazardous Materials, 398.


Sharma Shivika, & Chatterjee Subhankar. (2017). Microplastic pollution, a threat to marine ecosystem and human health: a short review. Environmental Science and Pollution Research, 24(27), 21530-21547.


Sherman, M. (2009). Vinyl chloride and the liver. Journal of Hepatology, Vol. 51, pp. 1074-1081.


Smith, M., Love, D. C., Rochman, C. M., & Neff, R. A. (2018, September 1). Microplastics in Seafood and the Implications for Human Health. Current Environmental Health Reports, Vol. 5, pp. 375-386.


Tacon, A. G. J., & Metian, M. (2008). Global overview on the use of fish meal and fish oil in industrially compounded aquafeeds: Trends and future prospects. Aquaculture, 285(1-4), 146-158.


Tan, H., Yue, T., Xu, Y., Zhao, J., & Xing, B. (2020). Microplastics Reduce Lipid Digestion in Simulated Human Gastrointestinal System. Environmental Science & Technology, 54(19), 12285-12294.


Tang, Y., Zhou, W., Sun, S., Du, X., Han, Y., Shi, W., & Liu, G. (2020). Immunotoxicity and neurotoxicity of bisphenol A and microplastics alone or in combination to a bivalve species, Tegillarca granosa. Environmental Pollution, 265.


Turcotte, S. E., Chee, A., Walsh, R., Grant, F. C., Liss, G. M., Boag, A., … Lougheed, M. D. (2013). Flock worker's lung disease: Natural history of cases and exposed workers in Kingston, Ontario. Chest, 143(6), 1642-1648.


Verla, A. W., Enyoh, C. E., Verla, E. N., & Nwarnorh, K. O. (2019). Microplastic-toxic chemical interaction: a review study on quantified levels, mechanism and implication. SN Applied Sciences, 1(11).


Vianello, A., Jensen, R. L., Liu, L., & Vollertsen, J. (2019). Simulating human exposure to indoor airborne microplastics using a Breathing Thermal Manikin. Scientific Reports, 9(1), 1-11.


Von Moos, N., Burkhardt-Holm, P., & Köhler, A. (2012). Uptake and effects of microplastics on cells and tissue of the blue mussel Mytilus edulis L. after an experimental exposure. Environmental Science and Technology, 46(20), 11327-11335.


Wright, S. L., & Kelly, F. J. (2017). Plastic and Human Health: A Micro Issue? Environmental Science and Technology, 51(12), 6634-6647.


Yin, L., Chen, B., Xia, B., Shi, X., & Qu, K. (2018). Polystyrene microplastics alter the behavior, energy reserve and nutritional composition of marine jacopever (Sebastes schlegelii). Journal of Hazardous Materials, 360, 97-105.


Yukioka, S., Tanaka, S., Nabetani, Y., Suzuki, Y., Ushijima, T., Fujii, S., … Singh, S. (2020). Occurrence and characteristics of microplastics in surface road dust in Kusatsu (Japan), Da Nang (Vietnam), and Kathmandu (Nepal). Environmental Pollution, 256.


Zhu, B. K., Fang, Y. M., Zhu, D., Christie, P., Ke, X., & Zhu, Y. G. (2018). Exposure to nanoplastics disturbs the gut microbiome in the soil oligochaete Enchytraeus crypticus. Environmental Pollution, 239, 408-415.


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