Keywords
antioxidant
antidiabetic
wound healing
sedative
How to Cite
Abstract
Globally, medicinal herb intervention has become popular in treating many illnesses. Centella asiatica (C. asiatica), a plant native to Southeast Asia, is utilized extensively due to its pharmacological and therapeutic benefits attributed by its triterpenoids and saponins. It has been widely researched for a variety of medicinal properties, including antidiabetic, antioxidant, wound healing, reproductive, sedative, anxiolytic, digestive, gastric ulcer, cognitive, antidepressant, and anti-inflammatory effects. The sedative qualities are associated with regulating the HPA axis to mitigate stress and modulate GABAergic activity, while its capacity to promote collagen production, provide antioxidant protection, and lower inflammation aids in the healing of wounds. Owing to a wide range of literature on C. asiatica, the significant discoveries about various diseases are occasionally overlooked. Hence, more concise and succinct information is warranted. This review aimed to summarize the potential medicinal aspects of C. asiatica, highlighting the medicinal properties, physicochemical properties and health benefits along with future direction of the therapeutic potential. While many of the well-established properties and effects have been proven, the procurement of further clinical trials must be attended to involving the determination of standardized procedures and investigate the ultimate possible function of C. asiatica in treating diverse medical diseases, thus, to fully comprehend the therapeutic benefits of the herb. By possessing numerous pharmacological properties, C. asiatica could potentially offer greater assistance in the medical world for treating the patients while minimizing risks and mitigating degenerative effects.
References
Abbas, A. M., & Sakr, H. F. (2013). Effect of selenium and grape seed extract on indomethacin-induced gastric ulcers in rats. Journal of Physiology and Biochemistry, 69(3), 527-537.
https://doi.org/10.1007/s13105-013-0241-z
Abubakar, A. R., & Haque, M. (2020). Preparation of medicinal plants: basic extraction and fractionation procedures for experimental purposes. Journal of Pharmacy and Bioallied Sciences, 12(1), 1-10.
https://doi.org/10.4103/jpbs.JPBS_175_19
Agnihotri, A., & Aruoma, O. I. (2020). Alzheimer's disease and parkinson's disease: a nutritional toxicology perspective of the impact of oxidative stress, mitochondrial dysfunction, nutrigenomics and environmental chemicals. Journal of the American College of Nutrition, 39(1), 16-27.
https://doi.org/10.1080/07315724.2019.1683379
Ajebli, M., & Eddouks, M. (2019). The promising role of plant tannins as bioactive antidiabetic agents. Current Medicinal Chemistry, 26(25), 4852-4884.
https://doi.org/10.2174/0929867325666180605124256
Asadi, N., Bahmani, M., Kheradmand, A., & Rafieian-Kopaei, M. (2017). The impact of oxidative stress on testicular function and the role of antioxidants in improving it: a review. Journal of Clinical and Diagnostic Research, 11(5), IE01-IE05.
https://doi.org/10.7860/JCDR/2017/23927.9886
Azerad, R. (2016). Chemical structures, production and enzymatic transformations of sapogenins and saponins from Centella asiatica (L.) urban. Fitoterapia, 114, 168-187.
https://doi.org/10.1016/j.fitote.2016.07.011
Azis, H. A., Taher, M., Ahmed, A. S., Sulaiman, W. M. A. W., Susanti, D., Chowdhury, S. R., & Zakaria, Z. A. (2017). In vitro and in vivo wound healing studies of methanolic fraction of Centella asiatica extract. South African Journal of Botany, 108, 163-174.
https://doi.org/10.1016/j.sajb.2016.10.022
Bhatnagar, M., Goel, I., Roy, T., Shukla, S. D., & Khurana, S. (2017). Complete comparison display (CCD) evaluation of ethanol extracts of Centella asiatica and Withania somnifera shows that they can non-synergistically ameliorate biochemical and behavioural damages in MPTP induced parkinson's model of mice. PLoS One, 12(5), e0177254.
https://doi.org/10.1371/journal.pone.0177254
Bunaim, M. K., Kamisah, Y., Mohd Mustazil, M. N., Fadhlullah Zuhair, J. S., Juliana, A. H., & Muhammad, N. (2021). Centella asiatica (L.) urb. prevents hypertension and protects the heart in chronic nitric oxide deficiency rat model. Frontiers in Pharmacology, 12, 742562.
https://doi.org/10.3389/fphar.2021.742562
Bundgaard Anker, C. C., Rafiq, S., & Jeppesen, P. B. (2019). Effect of steviol glycosides on human health with emphasis on type 2 diabetic biomarkers: a systematic review and meta-analysis of randomized controlled trials. Nutrients, 11(9), 1965.
https://doi.org/10.3390/nu11091965
Buranasudja, V., Rani, D., Malla, A., Kobtrakul, K., & Vimolmangkang, S. (2021). Insights into antioxidant activities and anti-skin-aging potential of callus extract from Centella asiatica (L.). Scientific Reports, 11(1), 13459.
https://doi.org/10.1038/s41598-021-92958-7
Bylka, W., Znajdek-Awizen, P., Studzinska-Sroka, E., & Brzezinska, M. (2013). Centella asiatica in cosmetology. Advances in Dermatology and Allergology, 30(1), 46-49.
https://doi.org/10.5114/pdia.2013.33378
Camacho-Alonso, F., Torralba-Ruiz, M. R., Garcia-Carrillo, N., Lacal-Lujan, J., Martinez-Diaz, F., & Sanchez-Siles, M. (2019). Effects of topical applications of porcine acellular urinary bladder matrix and Centella asiatica extract on oral wound healing in a rat model. Clinical Oral Investigations, 23(5), 2083-2095.
https://doi.org/10.1007/s00784-018-2620-x
Cao, S. Y., Wang, W., Nan, F. F., Liu, Y. N., Wei, S. Y., Li, F. F., & Chen, L. (2018). Asiatic acid inhibits LPS-induced inflammatory response in endometrial epithelial cells. Microbial Pathogenesis, 116, 195-199.
https://doi.org/10.1016/j.micpath.2018.01.022
Chaisawang, P., Sirichoat, A., Chaijaroonkhanarak, W., Pannangrong, W., Sripanidkulchai, B., Wigmore, P., & Welbat, J. U. (2017). Asiatic acid protects against cognitive deficits and reductions in cell proliferation and survival in the rat hippocampus caused by 5-fluorouracil chemotherapy. PLoS One, 12(7), e0180650.
https://doi.org/10.1371/journal.pone.0180650
Chanana, P., & Kumar, A. (2016). Possible involvement of nitric oxide modulatory mechanisms in the neuroprotective effect of Centella asiatica against sleep deprivation induced anxiety like behaviour, oxidative damage and neuroinflammation. Phytotherapy Research, 30(4), 671-680.
https://doi.org/10.1002/ptr.5582
Chandrika, U. G., & Kumarab, P. A. A. S. P. (2015). Gotu kola (Centella asiatica): nutritional properties and plausible health benefits. Advances in Food and Nutrition Research, 76, 125-157.
https://doi.org/10.1016/bs.afnr.2015.08.001
Chen, Y. N., Wu, C. G., Shi, B. M., Qian, K., & Ding, Y. (2018). The protective effect of asiatic acid on podocytes in the kidney of diabetic rats. American Journal of Translational Research, 10(11), 3733–3741.
Choi, Y. M., An, S., Lee, J., Lee, J. H., Lee, J. N., Kim, Y. S., Ahn, K. J., An, I. S., & Bae, S. (2017). Titrated extract of Centella asiatica increases hair inductive property through inhibition of STAT signaling pathway in three-dimensional spheroid cultured human dermal papilla cells. Bioscience, Biotechnology, and Biochemistry, 81(12), 2323-2329.
https://doi.org/10.1080/09168451.2017.1385383
Dahanukar, S., Kulkarni, R., & Rege, N. (2000). Pharmacology of medicinal plants and natural products. Indian Journal of Pharmacology, 32(4), S81-S118.
Das, K., Tiwari, R. K. S., & Shrivastava, D. K. (2010). Techniques for evaluation of medicinal plant products as antimicrobial agent: current methods and future trends. Journal of Medicinal Plants Research, 4(2).
https://doi.org/10.5897/JMPR09.030
de Kretser, D. M. (2004). Is spermatogenic damage associated with leydig cell dysfunction? The Journal of Clinical Endocrinology & Metabolism, 89(7), 3158-3160.
https://doi.org/10.1210/jc.2004-0741
de Padua, L. S., Bunyapraphatsara, N., & Lemmens, R. H. M. J. (1999). Plant resources of south-east asia. Medicinal and Poisonous Plants, 12(1).
Doknark, S., Mingmalairak, S., Vattanajun, A., Tantisira, B., & Tantisira, M. H. (2014). Study of ameliorating effects of ethanolic extract of Centella asiatica on learning and memory deficit in animal models. Journal of the Medical Association of Thailand, 97(Suppl 2), S68–S76.
El-Ashmawy, N. E., Khedr, E. G., El-Bahrawy, H. A., & Selim, H. M. (2016). Nebivolol prevents indomethacin-induced gastric ulcer in rats. Journal of Immunotoxicology, 13(4), 580-589.
https://doi.org/10.3109/1547691X.2016.1142488
Fard, S. E., Tafvizi, F., & Torbati, M. B. (2018). Silver nanoparticles biosynthesised using Centella asiatica leaf extract: apoptosis induction in MCF-7 breast cancer cell line. IET Nanobiotechnology, 12(7), 994-1002.
https://doi.org/10.1049/iet-nbt.2018.5069
Fitriawan, A. S., Widayati, R. W., Setyaningsih, W. A. W., Arfian, N., & Sari, D. C. R. (2019). Antidiabetic and hypolipidemic effect of Centella asiatica extract in streptozotocin induced diabetic rats. Healthy and Active Ageing. 1st International Respati Health Conference Universiti Respati Yogyakarta.
Flora, S. J., & Gupta, R. (2007). Beneficial effects of Centella asiatica aqueous extract against arsenic-induced oxidative stress and essential metal status in rats. Phytotherapy Research, 21(10), 980-988.
https://doi.org/10.1002/ptr.2208
Francis, S. C., & Thomas, M. T. (2016). Essential oil profiling of Centella asiatica (L.) Urb.‐ a medicinally important herb. South Indian Journal Of Biological Sciences, 2(1).
https://doi.org/10.22205/SIJBS%2F2016%2FV2%2FI1%2F100387
Ghiulai, R., Rosca, O. J., Antal, D. S., Mioc, M., Mioc, A., Racoviceanu, R., Macasoi, I., Olariu, T., Dehelean, C., Cretu, O. M., Voicu, M., & Soica, C. (2020). Tetracyclic and pentacyclic triterpenes with high therapeutic efficiency in wound healing approaches. Molecules, 25(23).
https://doi.org/10.3390/molecules25235557
Giribabu, N., Srinivasarao, N., Swapna Rekha, S., Muniandy, S., & Salleh, N. (2014). Centella asiatica attenuates diabetes induced hippocampal changes in experimental diabetic rats. Evidence-Based Complementary and Alternative Medicine, 2014, 592062.
https://doi.org/10.1155/2014/592062
Gohil, K. J., Patel, J. A., & Gajjar, A. K. (2010). Pharmacological review on Centella asiatica: a potential herbal cure-all. Indian Journal of Pharmaceutical Sciences, 72(5), 546-556.
https://doi.org/10.4103/0250-474X.78519
Gray, N. E., Alcazar Magana, A., Lak, P., Wright, K. M., Quinn, J., Stevens, J. F., Maier, C. S., & Soumyanath, A. (2018). Centella asiatica - Phytochemistry and mechanisms of neuroprotection and cognitive enhancement. Phytochemistry Reviews, 17(1), 161-194.
https://doi.org/10.1007/s11101-017-9528-y
Gray, N. E., Sampath, H., Zweig, J. A., Quinn, J. F., & Soumyanath, A. (2015). Centella asiatica attenuates amyloid-beta-induced oxidative stress and mitochondrial dysfunction. Journal of Alzheimer's Disease, 45(3), 933-946.
https://doi.org/10.3233/JAD-142217
Gray, N. E., Zweig, J. A., Murchison, C., Caruso, M., Matthews, D. G., Kawamoto, C., Harris, C. J., Quinn, J. F., & Soumyanath, A. (2017). Centella asiatica attenuates Aβ-induced neurodegenerative spine loss and dendritic simplification. Neuroscience Letters, 646, 24-29.
https://doi.org/10.1016/j.neulet.2017.02.072
Gupta, Y. K., Veerendra Kumar, M. H., & Srivastava, A. K. (2003). Effect of Centella asiatica on pentylenetetrazole-induced kindling, cognition and oxidative stress in rats. Pharmacology Biochemistry and Behavior, 74(3), 579-585.
https://doi.org/10.1016/S0091-3057(02)01044-4
Haleagrahara, N., & Ponnusamy, K. (2010). Neuroprotective effect of Centella asiatica extract (CAE) on experimentally induced parkinsonism in aged sprague-dawley rats. The Journal of Toxicological Sciences, 35(1), 41-47.
https://doi.org/10.2131/jts.35.41
Hashim, P., Sidek, H., Helan, M. H., Sabery, A., Palanisamy, U. D., & Ilham, M. (2011). Triterpene composition and bioactivities of Centella asiatica. Molecules, 16(2), 1310-1322.
https://doi.org/10.3390/molecules16021310
Heidari, M., Heidari-Vala, H., Sadeghi, M. R., & Akhondi, M. M. (2012). The inductive effects of Centella asiatica on rat spermatogenic cell apoptosis in vivo. Journal of Natural Medicines, 66(2), 271-278.
https:/doi.org/10.1007/s11418-011-0578-y
Hsu, Y. M., Hung, Y. C., Hu, L., Lee, Y. J., & Yin, M. C. (2015). Anti-diabetic effects of madecassic acid and rotundic acid. Nutrients, 7(12), 10065-10075.
https://doi.org/10.3390/nu7125512
Hussain, T., Tan, B., Murtaza, G., Liu, G., Rahu, N., Saleem Kalhoro, M., Hussain Kalhoro, D., Adebowale, T. O., Usman Mazhar, M., Rehman, Z. U., Martinez, Y., Akber Khan, S., & Yin, Y. (2020). Flavonoids and type 2 diabetes: evidence of efficacy in clinical and animal studies and delivery strategies to enhance their therapeutic efficacy. Pharmacological Research, 152, 104629. https://doi.org/10.1016/j.phrs.2020.104629
Hussein, S., Halmi, M. I. E., & Ling, A. P. K. (2017). The modified gompertz model demonstrates a variable growth rate between two Centella asiatica phenotypes. Journal Of Biochemistry Microbiology And Biotechnology, 1(43), 110-119.
Hyun-Young, S., Hoon, K., Eun-Jin, J., Jeung-Eun, K., Kyeong-Haeng, L., Yun-Jeong, B., & Kwang-Won, Y. (2020). Bioactive compounds, anti-oxidant activities and anti-inflammatory activities of solvent extracts from Centella asiatica cultured in Chungju. The Korean Journal of Food And Nutrition, 33(6), 692-701.
https://doi.org/10.9799/ksfan.2020.33.6.692
Idrus, R., Yunus, M. H. M., Simat, S. F., Sainik, N. Q. A. V., Adenan, M. I., & Saim, A. (2018). Aqueous extract of Centella asiatica as a potential anti-keloid agent. International Journal of Pharmaceutical Sciences and Research, 9(3).
https://doi.org/10.13040/ijpsr.0975-8232.9(3).1281-90
Intararuchikul, T., Teerapattarakan, N., Rodsiri, R., Tantisira, M., Wohlgemuth, G., Fiehn, O., & Tansawat, R. (2019). Effects of Centella asiatica extract on antioxidant status and liver metabolome of rotenone-treated rats using GC-MS. Biomedical Chromatography, 33(2), e4395.
https://doi.org/10.1002/bmc.4395
Jagadeesan, S., Chiroma, S. M., Mohd Moklas, M. A., Hidayat Baharuldin, M. T., Mat Taib, C. N., Amom, Z., Vishnumukkala, T., Thomas, W., & Mahdi, O. (2022). Centella asiatica L. urban protects against morphological aberrations induced by chronic unpredictable mild stress in rat’s hippocampus via attenuation of oxidative stress. Egyptian Journal of Basic and Applied Sciences, 9(1), 324-339.
https://doi.org/10.1080/2314808x.2022.2091265
James, J. T., & Dubery, I. A. (2009). Pentacyclic triterpenoids from the medicinal herb, Centella asiatica (L.) urban. Molecules, 14(10), 3922-3941.
https://doi.org/10.3390/molecules14103922
Jana, U., Sur Tk Fau - Maity, L. N., Maity Ln Fau - Debnath, P. K., Debnath Pk Fau - Bhattacharyya, D., & Bhattacharyya, D. (2010). A clinical study on the management of generalized anxiety disorder with Centella asiatica. Nepal Medical College Journal, 12(1):8-11.
Ju Ho, P., Jun Sung, J., Ki Cheon, K., & Jin Tae, H. (2018). Anti-inflammatory effect of Centella asiatica phytosome in a mouse model of phthalic anhydride-induced atopic dermatitis. Phytomedicine, 43, 110-119.
https://doi.org/10.1016/j.phymed.2018.04.013
Kabir, A. U., Samad, M. B., D’Costa, N. M., Akhter, F., Ahmed, A., & Hannan, J. (2014). Anti-hyperglycemic activity of Centella asiatica is partly mediated by carbohydrase inhibition and glucose-fiber binding. BMC Complementary and Alternative Medicine, 14(31).
https:/doi.org/10.1186/1472-6882-14-31
Khairuddin, N. H. (2016). Properties of asiaticoside in suppressing hyperpermeability in human umbilical vein endothelial cells induced by interferon-gamma (master's thesis). Universiti Putra Malaysia.
http://psasir.upm.edu.my/id/eprint/76281/1/FPSK%28M%29%202017%2075%20IR.pdf
Kong, D., Fu, P., Zhang, Q., Ma, X., & Jiang, P. (2019). Protective effects of Asiatic acid against pelvic inflammatory disease in rats. Experimental and Therapeutic Medicine, 17(6), 4687-4692.
https://doi.org/10.3892/etm.2019.7498
Krishnamurthy, R. G., Senut, M.-C., Zemke, D., Min, J., Frenkel, M. B., Greenberg, E. J., Yu, S.-W., Ahn, N., Goudreau, J., Kassab, M., Panickar, K. S., & Majid, A. (2009). Asiatic acid, a pentacyclic triterpene from Centella asiatica, is neuroprotective in a mouse model of focal cerebral ischemia. Journal of Neuroscience Research, 87(11), 2541-2550.
https:/doi.org/10.1002/jnr.22071
Kumar, V. (2020). Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets. International Immunopharmacology, 89(Pt B), 107087.
https://doi.org/10.1016/j.intimp.2020.107087
Kumari, S., Deori, M., Elancheran, R., Kotoky, J., & Devi, R. (2016). In vitro and in vivo antioxidant, anti-hyperlipidemic properties and chemical characterization of Centella asiatica (L.) extract. Frontiers in Pharmacology, 7, 400.
https://doi.org/10.3389/fphar.2016.00400
Legiawati, L., Fadilah, F., Bramono, K., & Indriatmi, W. (2018). In silico study of Centella asiatica active compounds as anti-inflammatory agent by decreasing IL-1 and IL-6 activity, promoting IL-4 activity. Journal of Pharmaceutical Sciences and Research, 10, 2142-2147.
Masola, B., Oguntibeju, O. O., & Oyenihi, A. B. (2018). Centella asiatica ameliorates diabetes-induced stress in rat tissues via influences on antioxidants and inflammatory cytokines. Biomedicine & Pharmacotherapy, 101, 447-457.
https://doi.org/10.1016/j.biopha.2018.02.115
Merhi, Z. (2014). Advanced glycation end products and their relevance in female reproduction. Human Reproduction, 29(1), 135-145.
https://doi.org/10.1093/humrep/det383
Newall, C. A., Anderson, L. A., & Phillipson, J. D. (1996). Herbal medicines: a guide for health-care professionals. The Pharmaceutical Press.
Nik, A. N. A. A. (2015). Antidepressant-like effects of Centella asiatica (Pegaga) extract on depression-induced rats. Universiti Teknologi Mara.
https://ir.uitm.edu.my/id/eprint/28005/
Oboh, M., Govender, L., Siwela, M., & Mkhwanazi, B. N. (2021). Anti-diabetic potential of plant-based pentacyclic triterpene derivatives: progress made to improve efficacy and bioavailability. Molecules, 26(23).
https://doi.org/10.3390/molecules26237243
Okonofua, F. E., Ntoimo, L. F. C., Omonkhua, A., Ayodeji, O., Olafusi, C., Unuabonah, E., & Ohenhen, V. (2022). Causes and risk factors for male infertility: a scoping review of published studies. International Journal of General Medicine, 15, 5985-5997.
https://doi.org/10.2147/IJGM.S363959
Orhan, I. E. (2012). Centella asiatica (L.) urban: from traditional medicine to modern medicine with neuroprotective potential. Evidence-Based Complementary and Alternative Medicine, 2012, 946259.
https://doi.org/10.1155/2012/946259
Oyenihi, A. B., Chegou, N. N., Oguntibeju, O. O., & Masola, B. (2017). Centella asiatica enhances hepatic antioxidant status and regulates hepatic inflammatory cytokines in type 2 diabetic rats. Pharmaceutical Biology, 55(1), 1671-1678.
https://doi.org/10.1080/13880209.2017.1318293
Oyenihi, A. B., Langa, S. O. P., Mukaratirwa, S., & Masola, B. (2019). Effects of Centella asiatica on skeletal muscle structure and key enzymes of glucose and glycogen metabolism in type 2 diabetic rats. Biomedicine & Pharmacotherapy, 112, 108715.
https://doi.org/10.1016/j.biopha.2019.108715
Oyenihi, A. B., Opperman, M., Alabi, T. D., Mpahleni, B., & Masola, B. (2020). Centella asiatica alleviates diabetes-induced changes in fatty acid profile and oxidative damage in rat testis. Andrologia, 52(10), e13751.
https:/doi.org/10.1111/and.13751
Park, K. S. (2021). Pharmacological Effects of Centella asiatica on skin diseases: evidence and possible mechanisms. Evidence-Based Complementary and Alternative Medicine, 2021, 5462633.
https://doi.org/10.1155/2021/5462633
Plengmuankhae, W., & Tantitadapitak, C. (2015). Low temperature and water dehydration increase the levels of asiaticoside and madecassoside in Centella asiatica (L.) urban. South African Journal of Botany, 97, 196-203.
https://doi.org/10.1016/j.sajb.2015.01.013
Practice Committee of the American Society for Reproductive Medicine. (2014). Report on varicocele and infertility: a committee opinion. In Fertility and Sterility, 102(6), 1556-1560.
Prakash, A., & Kumar, A. (2013). Mitoprotective effect of Centella asiatica against aluminum-induced neurotoxicity in rats: possible relevance to its anti-oxidant and anti-apoptosis mechanism. Neurological Sciences, 34(8), 1403-1409.
https://doi.org/10.1007/s10072-012-1252-1
Prakash, V., Jaiswal, N., & Srivastava, M. (2017). A review on medicinal properties of Centella asiatica. Asian Journal of Pharmaceutical and Clinical Research, 10(10).
https://doi.org/10.22159/ajpcr.2017.v10i10.20760
Puttarak, P., Dilokthornsakul, P., Saokaew, S., Dhippayom, T., Kongkaew, C., Sruamsiri, R., Chuthaputti, A., & Chaiyakunapruk, N. (2017). Effects of Centella asiatica (L.) urb. on cognitive function and mood related outcomes: a systematic review and meta-analysis. Scientific Reports, 7(1), 10646.
https://doi.org/10.1038/s41598-017-09823-9
Rahman, M. M., Sayeed, M. S., M.A., H., Hassan, M. M., & Islam, S. M. A. (2012). Phytochemical screening, antioxidant, anti-alzheimer and anti-diabetic activities of Centella asiatica. Journal of Natural Product Plant Resources, 2(4).
Rajakumari, S. (2010). Enhancement of memory in rats with Centella asiatica. Biomedical Research Volume Biomedical Research, 21(4), 429-432.
Ramachandran, V., & Saravanan, R. (2015). Glucose uptake through translocation and activation of GLUT4 in PI3K/Akt signaling pathway by asiatic acid in diabetic rats. Human & Experimental Toxicology, 34(9), 884-893.
https://doi.org/10.1177/0960327114561663
Ramaswamy, A. S. (1970). Pharmacological studies on Centella asiatica Linn. (brahma manduki)(no umbelliferae). Journal of Research in Industrial Medicine, 3(2), 45-56.
Rasouli, H., Hosseini-Ghazvini, S. M.-B., & Khodarahmi, R. (2019). Therapeutic potentials of the most studied flavonoids: highlighting antibacterial and antidiabetic functionalities. In Studies in Natural Products Chemistry (Vol. 60, pp. 85-122).
https://doi.org/10.1016/b978-0-444-64181-6.00003-6
Razali, N. N. M., Ng, C. T., & Fong, L. Y. (2019). Cardiovascular protective effects of Centella asiatica and its triterpenes: a review. Planta Medica, 85(16), 1203-1215.
https://doi.org/10.1055/a-1008-6138
Ren, L., Cao, Q. X., Zhai, F. R., Yang, S. Q., & Zhang, H. X. (2016). Asiatic acid exerts anticancer potential in human ovarian cancer cells via suppression of PI3K/Akt/mTOR signalling. Pharmaceutical Biology, 54(11), 2377-2382.
https://doi.org/10.3109/13880209.2016.1156709
Rocha, F. F., Almeida, C. S., Santos, R. T. d., Santana, S. A., Costa, E. A., Paula, J. R. d., & Vanderlinde, F. A. (2011). Anxiolytic-like and sedative effects of Hydrocotyle umbellata L., araliaceae, extract in mice. Revista Brasileira de Farmacognosia, 21(1), 115-120.
https://doi.org/10.1590/s0102-695x2011005000018
Ruksiriwanich, W., Khantham, C., Sringarm, K., Sommano, S., & Jantrawut, P. (2020). Depigmented Centella asiatica extraction by pretreated with supercritical carbon dioxide fluid for wound healing application. Processes, 8(3), 1-15.
https:/doi.org/10.3390/pr8030277
Sabaragamuwa, R., Perera, C. O., & Fedrizzi, B. (2018). Centella asiatica (Gotu kola) as a neuroprotectant and its potential role in healthy ageing. Trends in Food Science & Technology, 79, 88-97.
https://doi.org/10.1016/j.tifs.2018.07.024
Saeidinia, A., Keihanian, F., Lashkari, A. P., Lahiji, H. G., Mobayyen, M., Heidarzade, A., & Golchai, J. (2017). Partial-thickness burn wounds healing by topical treatment: A randomized controlled comparison between silver sulfadiazine and centiderm. Medicine (Baltimore), 96(9), e6168.
https://doi.org/10.1097/MD.0000000000006168
Sainath, S. B., Meena, R., Supriya, C., Reddy, K. P., & Reddy, P. S. (2011). Protective role of Centella asiatica on lead-induced oxidative stress and suppressed reproductive health in male rats. Environmental Toxicology and Pharmacology, 32(2), 146-154.
https://doi.org/10.1016/j.etap.2011.04.005
Sawatdee, S., Choochuay, K., Chanthorn, W., & Srichana, T. (2016). Evaluation of the topical spray containing Centella asiatica extract and its efficacy on excision wounds in rats. Acta Pharmaceutica, 66(2), 233-244.
https://doi.org/10.1515/acph-2016-0018
Sengul, E., & Gelen, V. (2019). Protective effects of naringin in indomethacin-induced gastric ulcer in rats. GSC Biological and Pharmaceutical Sciences, 8(2), 006-014.
https://doi.org/10.30574/gscbps.2019.8.2.0132
Sh Ahmed, A., Taher, M., Mandal, U. K., Jaffri, J. M., Susanti, D., Mahmood, S., & Zakaria, Z. A. (2019). Pharmacological properties of Centella asiatica hydrogel in accelerating wound healing in rabbits. BMC Complementary and Alternative Medicine, 19(1), 213.
https://doi.org/10.1186/s12906-019-2625-2
Shamsi, Y., & Jabin, A. (2018). Brahmi (Centella asiatica Linn.): a natural nootropic. Indian Journal of Unani Medicine, 11(1), 22-27.
Shen, X., Guo, M., Yu, H., Liu, D., Lu, Z., & Lu, Y. (2019). Propionibacterium acnes related anti-inflammation and skin hydration activities of madecassoside, a pentacyclic triterpene saponin from Centella asiatica. Bioscience, Biotechnology, and Biochemistry, 83(3), 561-568.
https://doi.org/10.1080/09168451.2018.1547627
Shukla, A., Rasik, A. M., & Dhawan, B. N. (1999). Asiaticoside-induced elevation of antioxidant levels in healing wounds. Phytotherapy Research, 13.
https:/doi.org/10.1002/(sici)1099-1573(199902)13:1%3C50::aid-ptr368%3E3.0.co;2-v
Singh, S., Gautam, A., Sharma, A., & Batra, A. (2010). Centella asiatica (L.): a plant with immense medicinal potential but threatened. International Journal of Pharmaceutical Sciences Review and Research, 4(2), 12-18.
Somboonwong, J., Kankaisre, M., Tantisira, B., & Tantisira, M. H. (2012). Wound healing activities of different extracts of Centella asiatica in incision and burn wound models: an experimental animal study. BMC Complementary and Alternative Medicine, 12(103).
https://doi.org/10.1186/1472-6882-12-103
Sorg, H., Tilkorn, D. J., Hager, S., Hauser, J., & Mirastschijski, U. (2017). Skin wound healing: an update on the current knowledge and concepts. European Surgical Research, 58(1-2), 81-94.
https://doi.org/10.1159/000454919
Soumyanath, A., Zhong, Y.-P., Henson, E., Wadsworth, T., Bishop, J., Gold, B. G., & Quinn, J. F. (2012). Centella asiatica extract improves behavioral deficits in a mouse model of alzheimer's disease: investigation of a possible mechanism of action. International Journal of Alzheimer’s Disease, 2012, 381974.
https://doi.org/10.1155/2012/381974
Soumyanath, A., Zhong, Y.-P., Yu, X., Bourdette, D., Koop, D. R., Gold, S. A., & Gold, B. G. (2005). Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro. Journal of Pharmacy and Pharmacology, 57(9), 1221-1229.
https://doi.org/10.1211/jpp.57.9.0018
Stefan, S. P., & Temidayo, S. (2018). Diabetes mellitus and male infertility. Asian Pacific Journal of Reproduction, 7(1).
https://doi.org/10.4103/2305-0500.220978
Subaraja, M., & Vanisree, A. J. (2019). Counter effects of asiaticosids-d through putative neurotransmission on rotenone induced cerebral ganglionic injury in Lumbricus terrestris. IBRO Reports, 6, 160-175.
https:/doi.org/10.1016/j.ibror.2019.04.003
Sun, B., Wu, L., Wu, Y., Zhang, C., Qin, L., Hayashi, M., Kudo, M., Gao, M., & Liu, T. (2020). Therapeutic potential of Centella asiatica and its triterpenes: a review. Frontiers in Pharmacology, 11, 568032.
https:/doi.org/10.3389/fphar.2020.568032
Sunilkumar, P, & Shivakumar, H. G. (1998). Evaluation of topical formulations of aqueous extract of Centella asiatica on open wounds in rats. Indian Journal of Experimental Biology, 36(6):569-572.
Tabassum, R., Vaibhav, K., Shrivastava, P., Khan, A., Ejaz Ahmed, M., Javed, H., Islam, F., Ahmad, S., Saeed Siddiqui, M., Safhi, M. M., & Islam, F. (2013). Centella asiatica attenuates the neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion rats. Neurological Sciences, 34(6), 925-933.
https://doi.org/10.1007/s10072-012-1163-1
Thirza, S. Q., Pratiwi, M. D., Noviardi, D. E. P. P., Sriepinndonta, P. M., Fitriani, F. N., Kalsum, U., Khotimah, H., Mintaroem, K., & Norahmawati, E. (2021). Anti-inflammatory effects of Centella asiatica ethanolic extracts towards indomethacin-induced gastric ulcer model in rats by altering COX-2 expression. AIP Conference Proceedings, 2353(1), 030062.
https://doi.org/10.1063/5.0053025
Umka Welbat, J., Sirichoat, A., Chaijaroonkhanarak, W., Prachaney, P., Pannangrong, W., Pakdeechote, P., Sripanidkulchai, B., & Wigmore, P. (2016). Asiatic acid prevents the deleterious effects of valproic acid on cognition and hippocampal cell proliferation and survival. Nutrients, 8(5).
https://doi.org/10.3390/nu8050303
Utami, N. P. B. S., & Farida, S. (2019). Centella asiatica as a potential plaque stabilizer: future preventive therapy for cardiovascular disease. AIP Conference Proceedings, 10 December 2019; 2193(1): 040008.
https://doi.org/10.1063/1.5139370
Vyawahare, N. S., Deshmukh, V. V., Gadkari, M. R., & Kagathara, V. G. (2009). Plants with antiulcer activity. Pharmacognosy Reviews, 3(5), 118-125.
https://phcogrev.com/sites/default/files/PhcogRev-3-5-118.pdf
Wamser-Nanney, R. (2022). Types of childhood maltreatment, posttraumatic stress symptoms, and indices of fertility. Psychological Trauma: Theory, Research, Practice, and Policy, 14(8), 1263-1271.
https://doi.org/10.1037/tra0001169
Wang, C., Su, W., Su, X., Ni, G., Liu, T., & Kong, Y. (2015b). Synergy effects of three plant extracts on protection of gastric mucosa. Natural Product Communications, 10(11), 1934578X1501001146.
https://doi.org/10.1177/1934578X1501001146
Wang, L., Guo, T., Guo, Y., & Xu, Y. (2020). Asiaticoside produces an antidepressant‑like effect in a chronic unpredictable mild stress model of depression in mice, involving reversion of inflammation and the PKA/pCREB/BDNF signaling pathway. Molecular Medicine Reports, 22(3), 2364-2372.
https://doi.org/10.3892/mmr.2020.11305
Wang, X., Lu, Q., Yu, D. S., Chen, Y. P., Shang, J., Zhang, L. Y., Sun, H. B., & Liu, J. (2015a). Asiatic acid mitigates hyperglycemia and reduces islet fibrosis in Goto-Kakizaki rat, a spontaneous type 2 diabetic animal model. Chinese Journal of Natural Medicines, 13(7), 529-534.
https://doi.org/10.1016/S1875-5364(15)30047-9
Wannasarit, S., Mahattanadul, S., Issarachot, O., Puttarak, P., & Wiwattanapatapee, R. (2020). Raft-forming gastro-retentive formulations based on Centella asiatica extract-solid dispersions for gastric ulcer treatment. European Journal of Pharmaceutical Sciences, 143, 105204.
https://doi.org/10.1016/j.ejps.2019.105204
Wijeweera, P., Arnason, J. T., Koszycki, D., & Merali, Z. (2006). Evaluation of anxiolytic properties of Gotukola--(Centella asiatica) extracts and asiaticoside in rat behavioral models. Phytomedicine, 13(9-10), 668-676.
https:/doi.org/10.1016/j.phymed.2006.01.011
Wu, Z. W., Li, W. B., Zhou, J., Liu, X., Wang, L., Chen, B., Wang, M. K., Ji, L., Hu, W. C., & Li, F. (2020). Oleanane- and ursane-type triterpene saponins from Centella asiatica exhibit neuroprotective effects. Journal of Agricultural and Food Chemistry, 68(26), 6977-6986.
https://doi.org/10.1021/acs.jafc.0c01476
Yahfoufi, N., Mallet, J. F., Graham, E., & Matar, C. (2018). Role of probiotics and prebiotics in immunomodulation. Current Opinion in Food Science, 20, 82-91.
https://doi.org/10.1016/j.cofs.2018.04.006
Yanti Eff, A. R., Hurit, H. E., Rahayu, S. T., Unggul Januarko, M., & Maya Wm, P. G. (2020). Antihypertensive, antidiabetic, antioxidant and cytotoxic activities of indonesian traditional medicine. Pharmacognosy Journal, 12(6), 1623-1629.
https://doi.org/10.5530/pj.2020.12.222
Yao, C. H., Yeh, J. Y., Chen, Y. S., Li, M. H., & Huang, C. H. (2017). Wound-healing effect of electrospun gelatin nanofibres containing Centella asiatica extract in a rat model. Journal of Tissue Engineering and Regenerative Medicine, 11(3), 905-915.
https://doi.org/10.1002/term.1992
Yasurin, P., & Pitinidhipat, N. (2012). Antibacterial activity of Chrysanthemum indicum, Centella asiatica and Andrographis paniculata against Bacillus cereus and Listeria monocytogenes under osmotic stress. AU Journal of Technology, 15, 239-245.
Yin, Z., Yu, H., Chen, S., Ma, C., Ma, X., Xu, L., Ma, Z., Qu, R., & Ma, S. (2015). Asiaticoside attenuates diabetes-induced cognition deficits by regulating PI3K/Akt/NF-κB pathway. Behavioural Brain Research, 292, 288-299.
https:/doi.org/10.1016/j.bbr.2015.06.024
Yunianto, I., Das, S., & Mat Noor, M. (2010). Antispermatogenic and antifertility effect of pegaga (Centella asiatica L.) on the testis of male sprague-dawley rats. Clinical Therapeutics, 161(3), 235-239.
Yunianto, I., Das, S., Mat Noor, M. (2017). Antifertility properties of Centella asiatica ethanolic extract as a contraceptive agent: Preliminary study of sperm proteomic. Asian Pacific Journal of Reproduction, 6(5).
https:/doi.org/10.4103/2305-0500.215931
Zainol, M. K., Abd-Hamid, A., Yusof, S., & Muse, R. (2003). Antioxidative activity and total phenolic compounds of leaf, root and petiole of four accessions of Centella asiatica (L.) urban. Food Chemistry, 81(4), 575-581.
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